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December 8, 2025Scientific ReportsOpen Access

Synergistic chemo-photothermal therapy using doxorubicin-loaded gold nanorods for enhanced apoptosis in lung cancer cells

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Authors

HGHamid GalehdariMSMohammad Sabaeian

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Overview

Combination therapy enhances apoptosis in lung cancer cells, suggesting a new approach to overcome drug resistance.

Key Points

  • This research aims to evaluate a synergistic approach to treat lung cancer using doxorubicin and photothermal therapy.
  • Combined doxorubicin-loaded gold nanorods with near-infrared laser irradiation
  • Evaluated apoptosis using gene expression profiling, TUNEL assay, and Western blot analysis
  • Investigated mechanistic pathways involving caspase activation in A549 lung cancer cells.
  • Combined treatment induced apoptosis in nearly 60% of A549 cells, surpassing other treatment modalities
  • Enhanced intracellular drug release and membrane permeability due to photothermal effects
  • Activated both intrinsic and extrinsic apoptotic pathways through caspase-3, caspase-8, and caspase-9.

Cite This Study

Galehdari et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cd65https://doi.org/10.1038/s41598-025-29565-3
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Also Consider

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  1. 1Synergistic Chemo-Photothermal Therapy Using Doxorubicin-Loaded Gold Nanorods for Enhanced Apoptosis in Lung Cancer Cells2025
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  4. 4Assembled Gold Superstructure Triggered Synergistic Apoptosis/Ferroptosis via Combined Photo-Enzyme Therapy2025
  5. 5NIR-Responsive Gold-Decorated Phase-Change Nanodroplets for Photothermal-Triggered Pulsatile Doxorubicin Release and Enhanced Combined Photothermal-Chemotherapy in Triple-Negative Breast Cancer2026 · 1 citations