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This is a Experimental Study study.

September 12, 2025

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes. v1

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Authors

APAlexandra PančíkováVIB-KU Leuven Center for Cancer Biology RCRuben Cools MEMarios EftychiouVIB-KU Leuven Center for Cancer Biology

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Implication

Research showcases a modified 10X protocol that combines RNA and epigenomic profiling at a single-cell level, revealing insights into gene regulation.

Key Points

The SPLONGGET method captures comprehensive single-cell data on genome, transcriptome, and open chromatin, enhancing the understanding of cellular functions.
Using the 10X Multiome assay, the approach integrates both gene expression and epigenomic profiles for deeper insights into cell biology.
This method modifies existing techniques to allow for fragment-length independent sequencing, making it a versatile tool in multiomic studies.
Findings suggest that this integrated profiling could significantly impact research into gene regulation and cellular heterogeneity.

Cite This Study

Pančíková et al. (2025) studied this question.

synapsesocial.com/papers/68d44c5531b076d99fa56263 https://doi.org/10.17504/protocols.io.kqdg3wdwpv25/v1

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Implication

Research showcases a modified 10X protocol that combines RNA and epigenomic profiling at a single-cell level, revealing insights into gene regulation.

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes. v1

Discussion

Member takes

Implication

Key Points

Cite This Study

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes. v1

Discussion

Member takes

Implication

Key Points

Cite This Study

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