What type of study is this?

This is a Quantitative Study study.

September 16, 2025Open Access

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes.

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Authors

APAlexandra PančíkováVIB-KU Leuven Center for Cancer Biology RCRuben CoolsVIB-KU Leuven Center for Cancer Biology MEMarios EftychiouVIB-KU Leuven Center for Cancer Biology

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Implication

This method demonstrates the integration of genome and transcriptome data in single cells, highlighting genetic variations and their phenotypic consequences.

Key Points

SPLONGGET reveals connections between genetic variations and phenotypes in single cells, including cancer.
The approach simultaneously profiles genome, transcriptome, and chromatin accessibility in thousands of single cells.
Utilizing single-cell profiling, the technique enables detailed analysis of variants in paediatric leukaemia cases.
This integrated methodology offers a powerful tool for studying genetically diverse samples, aiding in cancer and aging research.

Cite This Study

Pančíková et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7b31b076d99fa56e35 https://doi.org/10.1101/2025.09.08.674950

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Implication

This method demonstrates the integration of genome and transcriptome data in single cells, highlighting genetic variations and their phenotypic consequences.

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes.

Discussion

Member takes

Implication

Key Points

Cite This Study

Long-read single-cell genome, transcriptome and open chromatin profiling links genotype to phenotypes.

Discussion

Member takes

Implication

Key Points

Cite This Study

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