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September 16, 2025Expert Review of Hematology

Lower rates of maternal morbidities among pregnant women suffering from sickle cell disease who are exposed to hydroxyurea, a retrospective study from tribal area of Western India

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Authors

GDGayatri DesaiHBHasmukh BalarKDKapilkumar Dave

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Overview

Retrospective study examines maternal morbidity and fetal outcomes in women with sickle cell disease receiving hydroxyurea, indicating potential benefits.

Key Points

  • Hydroxyurea use in pregnancy lowered maternal morbidity rates significantly, reducing complications.
  • The adverse maternal event score in the hydroxyurea group was 91.2 per 100 person-months, compared to 109.8 in the control group.
  • A retrospective analysis of 235 pregnant women with sickle cell disease was conducted to evaluate maternal and fetal outcomes.
  • Results suggest that hydroxyurea may be a safer option in managing maternal morbidity during pregnancy, requiring further prospective studies.

Cite This Study

Desai et al. (2025) studied this question.

synapsesocial.com/papers/68d44f8331b076d99fa57233https://doi.org/10.1080/17474086.2025.2562080
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