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December 8, 2025Blood

Outcomes of pregnancies in sickle cell patients treated with hydroxyurea : Findings from the escort-HU cohort studies

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Authors

AHAnoosha HabibiNENarcisse ElengaSJSylvain Le Jeune

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Overview

Multicenter cohort studies demonstrate hydroxyurea maintains safety during pregnancy, linking to live birth rates in sickle cell disease patients.

Key Points

  • To assess pregnancy outcomes in sickle cell disease patients treated with hydroxyurea.
  • Prospective, multicenter, non-interventional cohort studies conducted in multiple European countries.
  • Enrolled a total of 3145 patients to track pregnancies and childbirth outcomes.
  • Documented pregnancies under hydroxyurea treatment as well as outcomes: live births, non-live births, and ongoing pregnancies.
  • Of 246 pregnancies, 76% resulted in live births.
  • No maternal mortality was reported, even in severe sickle cell cases.
  • Safety was observed in newborns with no reported malformations related to hydroxyurea exposure.

Cite This Study

Habibi et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e18ahttps://doi.org/10.1182/blood-2025-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lower rates of maternal morbidities among pregnant women suffering from sickle cell disease who are exposed to hydroxyurea, a retrospective study from tribal area of Western India2025
  2. 2Real-world effectiveness and safety of hydroxyurea in adults with hemoglobin SC disease: A retrospective cohort study in Quebec, Canada2025
  3. 3Hydroxyurea (hydroxycarbamide) use in adults with haemoglobin <scp>SC</scp> disease: A real‐world study in Quebec2026
  4. 4Is hydroxyurea treatment associated with an increased risk of malignancy in sickle cell disease? a propensity-matched analysis of 27,854 patients in the real world2025
  5. 5A65-05 Pulmonary Hypertension and Mortality in Adults With Sickle Cell Disease: Impact of Hydroxyurea Therapy vs. Chronic Transfusions2026