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September 16, 2025Naunyn-Schmiedeberg s Archives of PharmacologyOpen Access

Amelioration of intestinal ischemia reperfusion injury by diacerein via regulation of inflammasome/caspase-1/IL-1β and Wnt/β-catenin pathways in juvenile rats

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Authors

MRMarwa M. M. RefaieMinia UniversityNMNoreen MajeedLotus Clinical ResearchSSSayed ShehataMinia University

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Implication

Animal study finds diacerein improves outcomes of intestinal ischemia reperfusion injury, suggesting potential for enhancing treatment strategies.

Key Points

  • Diacerein significantly reduces cardiac enzyme levels, indicating effective protection against ischemic injury.
  • The study shows normalization of oxidative stress parameters in the presence of diacerein after ischemia reperfusion.
  • The model utilized involved randomly assigned juvenile rats undergoing surgical ischemia reperfusion and treatment.
  • These findings support the need for adjunctive therapies like diacerein in managing intestinal ischemia reperfusion damage.

Cite This Study

Refaie et al. (2025) studied this question.

synapsesocial.com/papers/68d44f8c31b076d99fa572d2https://doi.org/10.1007/s00210-025-04581-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diacerein Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction2015 · 33 citations
  2. 2Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis2021 · 100 citations
  3. 3Sevoflurane alleviates intestinal ischemia–reperfusion injury in aged mice2025 · 6 citations
  4. 4Hypoxia signaling during intestinal ischemia and inflammation2012 · 61 citations
  5. 5Kui Jie Tong Ameliorates Ulcerative Colitis by Regulating Gut Microbiota and NLRP3/Caspase-1 Classical Pyroptosis Signaling Pathway2022 · 37 citations