Figure 4 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

Fitness costs are observed in multiple platinum-resistant HGSC cell lines Abundance of three different sensitive (green) and resistant cell pairs (red) over time when grown as cocultures in low-resource conditions (0.5% FBS exchanged daily) at three starting ratios (85% sensitive, 50% sensitive, and 15% sensitive). A, Ov4Carbo: resistance evolved from OVCAR4 in vitro. B, IVR01: resistance evolved from OVCAR4 in vivo.C, Cov-Cis: resistance evolved from Cov318 in vitro. Solid lines indicate observed cell growth and dashed lines indicate predicted cell growth based on 100% monoculture experiments. Models are derived from three technical repeats.