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September 15, 2025

Supplementary Figure 7 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

Helen Hockings Eszter Lakatos Weini Huang Maximilian Mossner Mohammed A. Khan Nikolina Bakali Jacqueline McDermott Kane Smith Ann‐Marie Baker Trevor A. Graham Michelle Lockley

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Key Points

Long-term tumor control is achievable in chemotherapy-resistant ovarian cancer through adaptive therapy.
Quantitative PCR results demonstrate varying ratios of GFP and RFP positive cells in co-culture setups.
Co-culture ratios of OVCAR4 and Ov4Cis cells were tested from 100:0 to 0:100 across multiple groupings.
These findings may inform future approaches to enhance treatment effectiveness in resistant ovarian tumors.

Implication

Quantitative PCR assesses tumor cell ratios in chemotherapy-resistant ovarian cancer, indicating potential for long-term control.

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Cite This Study

Hockings et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa58899 https://doi.org/10.1158/0008-5472.30125896

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 8 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
2Supplementary Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
3Supplementary Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
4Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
5Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025

Supplementary Figure 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Figure 3 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Figure 7 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025