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September 15, 2025

Supplementary Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

Helen Hockings Eszter Lakatos Weini Huang Maximilian Mossner Mohammed A. Khan Nikolina Bakali Jacqueline McDermott Kane Smith Ann‐Marie Baker Trevor A. Graham Michelle Lockley

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Key Points

Gene expression of p16 and p21 significantly increased in chemotherapy-resistant ovarian cancer cells.
Doxorubicin treatment led to noteworthy changes in gene expression, with a p-value of less than 0.01.
The study utilized co-culture systems to analyze the interactions between different cell populations.
Findings suggest that adaptive therapy can effectively manage tumor control in resistant ovarian cancer.

Implication

Analysis demonstrates gene expression changes in ovarian cancer cells, indicating outcomes from adaptive therapy.

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Cite This Study

Hockings et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa58898 https://doi.org/10.1158/0008-5472.30125902

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
2Supplementary Figure 7 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
3Supplementary Figure 8 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
4Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
5Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025

Supplementary Figure 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Figure 4 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Supplementary Figure 2 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025