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September 15, 2025

Supplementary Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

Helen Hockings Eszter Lakatos Weini Huang Maximilian Mossner Mohammed A. Khan Nikolina Bakali Jacqueline McDermott Kane Smith Ann‐Marie Baker Trevor A. Graham Michelle Lockley

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Key Points

Long-term tumor control achieved in chemotherapy-resistant ovarian cancer with adaptive therapy, continuing to exploit fitness deficits.
Fluorescence measurements show OVCAR4 and Ov4Cis cell line behavior over 20 passages, with results indicating effective adaptive therapy.
In vitro analysis was conducted using technical replicates to ensure accuracy in measuring fluorescence of cancer cells.
Results may support the development of adaptive therapy strategies for improved outcomes in ovarian cancer management.

Implication

Analysis of chemotherapy-resistant ovarian cancer shows fluorescence changes in cell lines, indicating tumor control potential.

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Cite This Study

Hockings et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa58887 https://doi.org/10.1158/0008-5472.30125899

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 8 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
2Supplementary Figure 7 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
3Supplementary Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
4Supplementary Figure 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
5Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025

Supplementary Figure 3 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Supplementary Figure 2 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Figure 4 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025