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September 15, 2025

Supplementary Figure 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

Helen Hockings Eszter Lakatos Weini Huang Maximilian Mossner Mohammed A. Khan Nikolina Bakali Jacqueline McDermott Kane Smith Ann‐Marie Baker Trevor A. Graham Michelle Lockley

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Key Points

Adaptive therapy achieves long-term tumor control in chemotherapy-resistant ovarian cancer models.
Tumor growth in subcutaneous xenografts was measured over time, with assessments including three mice per cell line.
Analysis involved subcutaneous xenografts of OVCAR4 and Ov4Carbo in CD1nu/nu mice to exhibit treatment outcomes.
This approach suggests promising implications for managing chemotherapy-resistant tumors and enhancing patient outcomes.

Implication

Observational analysis shows tumor control in ovarian cancer models, highlighting adaptive therapy's potential effectiveness.

Abstract

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Cite This Study

Hockings et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa588a3 https://doi.org/10.1158/0008-5472.30125914

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 8 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
2Supplementary Figure 3 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
3Supplementary Figure 6 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
4Supplementary Figure 2 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
5Figure 1 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025

Supplementary Figure 5 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Figure 2 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025
Supplementary Figure 7 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control2025