Supplementary Figure 9 from Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control

A-Di: Tumour purity-corrected copy number profile for each sample obtained from patients UP0018 (A), UP0042 (B), UP0053 (C) and UP0056 (D). Grey bars show the copy number of each segment in the baseline diagnostic tumour biopsy sample and red bars show CN profile of later samples as indicated. A-Dii: Resistant proportion of each sample estimated by LiqCNA. Error bars indicate 95% confidence of each estimate. A-Diii: Zoomed-in profiles of selected chromosomes with the most prominent/impactful resistant-specific copy number alterations. Driver genes or genes associated with ovarian cancer that overlap with resistant-specific CNA are indicated by blue vertical lines and listed below each graph.