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September 16, 2025International Journal of Biological SciencesOpen Access

Comprehensive analytical approach identifies a subtype of CTCF+ tumor-associated neutrophils associated with CRC development and as a biomarker for immunotherapy

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Authors

JLJie-pin LiYLYuan‐jie LiuYZYi Zhang

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Overview

This analysis reveals CTCF+ tumor-associated neutrophils linked to CRC progression, suggesting new immunotherapy strategies.

Key Points

  • CTCF+ tumor-associated neutrophils drive colorectal cancer progression and immunosuppression, indicating their critical role in the tumor microenvironment.
  • Increased CTCF expression in tumor-associated neutrophils correlates with poor prognosis and resistance to immune therapy, particularly anti-PD-L1 treatment.
  • Integration of single-cell RNA sequencing and functional studies elucidates the relationship between CTCF+ neutrophils and CRC development.
  • Targeting the CTCF-MIEN1-IL-1β pathway shows promise in improving immunotherapy efficacy for colorectal cancer patients.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d454bb31b076d99fa59f41https://doi.org/10.7150/ijbs.111529
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Constructing prognostic models for colorectal cancer through dynamic profiling of tumor-associated neutrophils via single-cell and bulk RNA sequencing2024
  2. 2The Emerging Role of Tumor-Associated Neutrophils in Modulating Immune Checkpoint Inhibitor Response and Therapeutic Strategies2026
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  5. 5Integrative Single‐Cell and Spatial Transcriptomics Reveals the Crosstalk of CTHRC1+ CAF and MMP7+ Epithelial Axis as a Potential Therapeutic Target and Predicts Poor Clinical Outcomes in Colorectal Cancer2026 · 2 citations