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September 17, 2025Analytical Chemistry

Two-Dimensional LC × DMS Analysis of 34 PFAS Compounds

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Authors

CRChristopher R. M. RyanENEmir NazdrajićJCJ. Larry Campbell

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Overview

Analysis demonstrates enhanced baseline resolution for PFAS using liquid chromatography and differential mobility spectrometry, indicating valuable improvements for environmental monitoring.

Key Points

  • Incorporating DMS in a 2D separation scheme achieves baseline resolution of 29 PFAS compounds, enhancing detection capability.
  • LC × DMS analysis offers distinct trends in PFAS subclasses, facilitating identification of unknown species in future studies.
  • While the 2D method shows higher limits of quantitation than LC-MS2, it operates on a similar time scale for efficient analysis.
  • Quantification of PFOS was successfully achieved in wastewater samples, with concentrations surpassing those detected by LC-MS2.

Cite This Study

Ryan et al. (2025) studied this question.

synapsesocial.com/papers/68d4566c31b076d99fa5bb6dhttps://doi.org/10.1021/acs.analchem.5c04119
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