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September 17, 2025Bioresource TechnologyOpen Access

A combinatorial stress-alleviation strategy for efficient β-carotene production in Escherichia coli

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Authors

YJYuanqing JiMinistry of AgricultureJYJia YueGoddard Space Flight CenterYHYihong HuangPeking University

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Implication

Combining genetic modifications enhanced β-carotene yields in Escherichia coli, indicating a viable method for industrial applications.

Key Points

  • Enhanced β-carotene production reached 3.93 g/L, indicating a substantial increase in yield.
  • Genetic modifications targeting 16 precursors increased production efficiency by 619.79 mg/L, highlighting significant metabolic improvement.
  • Dynamic regulation of mvaE resulted in a 45.75% increase in β-carotene titer, suggesting effective metabolic control strategies.
  • A novel continuous fermentation approach enabled an average productivity of 81.9 mg/L/h, underscoring its industrial applicability.

Cite This Study

Ji et al. (2025) studied this question.

synapsesocial.com/papers/68d4567431b076d99fa5bf43https://doi.org/10.1016/j.biortech.2025.133336
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Also Consider

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  3. 3Rapid Gene Target Tracking for Enhancing β-Carotene Production Using Flow Cytometry-Based High-Throughput Screening in Yarrowia lipolytica2022 · 31 citations