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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Altered coupling between global signal and cerebrospinal fluid inflow in depressed patients following sleep deprivation

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Authors

WZWeiwei ZhaoShanghai International Studies UniversityYCYa ChaiIndiana University – Purdue University IndianapolisHRHengyi RaoShanghai International Studies University

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Implication

This study investigates gBOLD-CSF coupling and mood changes in depressed individuals after sleep deprivation.

Key Points

  • Depressed patients showed impaired glymphatic function resilience to sleep deprivation, affecting mood.
  • Mood changes were assessed through HDRS-17 after rfMRI scans in thirty depressed patients and thirty-seven healthy controls.
  • The study utilized dynamic rfMRI imaging to evaluate cerebrospinal fluid inflow coupling during total sleep deprivation.
  • These findings highlight the potential for therapeutic interventions targeting mood and brain health in depressive disorders.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c54fhttps://doi.org/10.58530/2025/4725
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced coupling between global signal and cerebrospinal fluid inflow in patients with depressive disorder: A resting state functional MRI study2024 · 44 citations
  2. 2Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity2026 · 2 citations
  3. 3Sleep deprivation exhibits age-dependent effect on infra-slow global brain activity2025
  4. 4Impaired Glymphatic System Function in Sleep-Deprived Individuals demonstrated by DTI-ALPS Index2025
  5. 5A multimodal 7T MRI and biomarker study reveals reversible brain changes following acute sleep deprivation2025