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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Impaired Glymphatic System Function in Sleep-Deprived Individuals demonstrated by DTI-ALPS Index

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Authors

YZYi‐Lei ZhaoShanghai Jiao Tong UniversityXDXi‐jian DaiNanchang UniversityWHWenjun HuangSeattle Children's Hospital

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Overview

Observational analysis found reduced glymphatic function in sleep-deprived individuals, suggesting implications for public health.

Key Points

  • Significantly lower glymphatic function was observed in participants after 24 hours of sleep deprivation.
  • The ALPS index measurement indicates alterations in glymphatic system functionality with changes post-recovery.
  • Diffusion tensor imaging analysis was utilized to assess the glymphatic function during the study.
  • This research highlights the potential of the DTI-ALPS index to evaluate glymphatic function in sleep deprivation.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c867https://doi.org/10.58530/2025/4668
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glymphatic dysfunction across sleep disorders: a meta-analysis of DTI-ALPS studies2026 · 1 citations
  2. 2Glymphatic system dysfunction in Primary Insomnia evidenced by diffusion tensor imaging with the perivascular space (DTI-ALPS)2024
  3. 3Glymphatic dysfunction impairs cognitive function via disrupted white matter network efficiency in primary insomnia: A DTI-ALPS mediation study2025 · 2 citations
  4. 4Altered coupling between global signal and cerebrospinal fluid inflow in depressed patients following sleep deprivation2025
  5. 5DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder2026 · 1 citations