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June 20, 2026Psychological MedicineOpen Access

DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder

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Authors

ZLZhangwei LvHZHaitao ZhangYYYanrong Yang

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Overview

Multimodal MRI study examines how sleep quality affects working memory through glymphatic function and structural-functional coupling in insomnia disorder.

Key Points

  • This research aims to explore the relationship between sleep quality, glymphatic function, structural-functional coupling, and working memory in insomnia disorder.
  • Conducted a multimodal MRI study involving 391 insomnia disorder patients.
  • Estimated glymphatic function using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS).
  • Performed partial correlations and mediation analyses to examine associations between sleep quality, DTI-ALPS, structural-functional coupling, and working memory performance.
  • DTI-ALPS showed a negative correlation with sleep quality (r = -0.17, p = 0.006), indicating glymphatic clearance decreases with poor sleep.
  • Global structural-functional coupling positively associated with DTI-ALPS (r = 0.32, pFDR < 0.001) but not with working memory performance (r = 0.01, p = 0.84).
  • Subcortical structural-functional coupling linked to both DTI-ALPS (r = 0.29, pFDR < 0.001) and working memory performance (r = 0.28, pFDR < 0.001), with mediation analysis indicating a significant indirect effect.

Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/6a3632a0db0793dc1a5392f4https://doi.org/10.1017/s0033291726104188
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