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September 18, 2025Open Access

Sleep deprivation exhibits age-dependent effect on infra-slow global brain activity

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Authors

YYYibing YangMinzu University of ChinaWZWeiwei ZhaoShanghai International Studies UniversityYMYutong MaoPennsylvania State University

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Implication

Controlled sleep deprivation increases gBOLD signal coupling with CSF dynamics in aging adults, suggesting implications for neurodegenerative diseases.

Key Points

  • Total sleep deprivation significantly increases the amplitude of the gBOLD signal, indicating altered brain activity.
  • Enhanced coupling of gBOLD signal with cerebrospinal fluid flow may improve waste clearance, especially after sleep loss.
  • Midlife individuals (40-50 years) show diminished responses in gBOLD activity after sleep deprivation, raising concerns about aging effects.
  • The lack of compensatory mechanisms in midlife could worsen neurotoxic clearance and elevate dementia risk.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68d461bc31b076d99fa60942https://doi.org/10.1101/2025.09.12.675828
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