Key result
Total sleep deprivation decreased alpha-band power, significantly increased delta-band power, and impaired functional connectivity in the default mode network and parietal lobules.
Why the study?
Total sleep deprivation causes cognitive decline, but the neurophysiological mechanisms underlying resting-state EEG changes after total sleep deprivation remain unclear.
Does total sleep deprivation alter resting-state EEG power spectra and functional connectivity in healthy adults?
Observational (n=42)
Does total sleep deprivation alter resting-state EEG power spectra and functional connectivity in healthy adults?
Total sleep deprivation alters resting-state EEG power and functional connectivity, with changes plateauing between 24 and 36 hours.
Hypothesis-generating for sleep deprivation effects on brain networks; larger trials needed before clinical translation.
Total sleep deprivation (TSD) leads to cognitive decline; however, the neurophysiological mechanisms underlying resting-state electroencephalogram (EEG) changes after TSD remain unclear. In this study, 42 healthy adult participants were subjected to 36 h of sleep deprivation (36 h TSD), and resting-state EEG data were recorded at baseline, after 24 h of sleep deprivation (24 h TSD), and after 36 h TSD. The analysis of resting-state EEG at baseline, after 24 h TSD, and after 36 h TSD using source localization analysis, power spectrum analysis, and functional connectivity analysis revealed a decrease in alpha-band power and a significant increase in delta-band power after TSD and impaired functional connectivity in the default mode network, precuneus, and inferior parietal lobule. The cortical activities of the precuneus, inferior parietal lobule, and superior parietal lobule were significantly reduced, but no difference was found between the 24 h and 36 h TSD groups. This may indicate that TSD caused some damage to the participants, but this damage temporarily slowed during the 24 h to 36 h TSD period.
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Lian et al. (2023) conducted an observational in Healthy (n=42). Total sleep deprivation vs. Baseline was evaluated on Resting-state EEG power spectra and functional connectivity. Total sleep deprivation decreased alpha-band power, significantly increased delta-band power, and impaired functional connectivity in the default mode network and parietal lobules.
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