This work demonstrates an Fe(II) complex's capability to detect hydrogen peroxide using MRI, implying its potential for biochemical sensing applications.
We report the fluorinated quinol-containing ligand, 1,8-bis(2,5-dihydroxy-4-fluorobenzyl)-1,4,8,11-tetraazacyclotetradecane (F2H4qp4), and its highly water- and air-stable Fe(II) complex. Upon oxidation by H2O2, the 19F MRI signal of the complex decays while its 1H MRI contrast increases; these spectroscopic responses enable the complex to ratiometrically detect H2O2.
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Karbalaei et al. (2025) studied this question.
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