Total Flavonoid Content, Antioxidant Properties, and COX Inhibition of a Dual-Extract Herbal Blend: Formulation of a Gel for Anti-Inflammatory and Wound-Healing Applications

The current work examined UDASP-HB, a novel herbal formulation comprising Urtica dioica methanol leaf extract and Angelica sinensis polysaccharide, for its pharmacological activity. It examined the total flavonoid content and its antioxidant and anti-inflammatory activity. UDASP-HB exhibited high concentrations of flavonoids, with considerable inhibition of lipid peroxidation in egg yolk and liver homogenate model compared with controls. UDASP-HB inhibited COX-1 and COX-2 enzymes and, therefore, can exhibit anti-inflammatory activity. Additionally, six new topical gel formulations and preparations were developed and examined for their physicochemical properties and in vitro drug delivery studies. All six preparations facilitated sustained delivery and effective dermal delivery.