September 17, 2025Iranian Journal of Public HealthOpen Access

Association between Thyrotoxicosis and Gestational Diabetes Mellitus: A Mendelian Randomization Study

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Authors

YCYizhen ChenZhejiang Chinese Medical University SGShaoxing GuanSun Yat-sen University XSXiaorong SuMinistry of Public Security of the People's Republic of China

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Implication

Mendelian randomization analysis finds a significant causal relationship between thyrotoxicosis and gestational diabetes, suggesting health implications.

Key Points

A causal relationship was established, revealing that thyrotoxicosis increases the risk of developing gestational diabetes.
The analysis indicated a strong association with an odds ratio of 1.087 in evaluating the impact of thyrotoxicosis on GDM.
Using multiple statistical methods, including inverse-variance weighted analysis, affirmed the findings without significant pleiotropy or heterogeneity.
Bayesian colocalization analysis identified the genetic correlation at rs10830963, linking thyrotoxicosis with gestational diabetes.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d4604031b076d99fa5f301 https://doi.org/10.18502/ijph.v54i8.19580

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Implication

Mendelian randomization analysis finds a significant causal relationship between thyrotoxicosis and gestational diabetes, suggesting health implications.

Association between Thyrotoxicosis and Gestational Diabetes Mellitus: A Mendelian Randomization Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Association between Thyrotoxicosis and Gestational Diabetes Mellitus: A Mendelian Randomization Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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