Erectile dysfunction and reproductive disorders in patients with chronic kidney disease

Introduction. Erectile dysfunction (ED) and associated reproductive disorders (RD) are a significant medical and social problem, especially in patients with chronic kidney disease (CKD). In this category of patients, the frequency of erectile and reproductive disorders is significantly higher than in the general population, which negatively affects their quality of life and psychoemotional state. Objective. The purpose of this review is to systematize current data on the prevalence, pathogenetic mechanisms and consequences of ED in patients with CKD and in kidney transplant recipients, as well as to analyze the effect of kidney transplantation (KT) on the restoration of sexual and reproductive function. Material and methods. The review includes homeland and foreign studies mostly published in the recent 5 years, which have devoted to the assessment of erectile function in patients with CKD and after KT. Particular attention is paid to the use of standardized assessment methods, such as the International Index of Erectile Function (IIEF-5), as well as the analysis of data on hormonal background, psychoemotional and social aspects. Conclusion. ED is a common complication of CKD caused by vascular, hormonal and psychoemotional factors. Effective treatment requires an interdisciplinary approach taking into account the somatic and psychological state of the patient. KT improves sexual function, but in some patients ED persists due to immunosuppression and concomitant diseases. Further research is needed to optimize diagnostics, therapy and improve the quality of life of such patients.