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September 18, 2025Plastic Surgery and Aesthetic Medicine

Morphological and immunohistochemical characteristics of skin specimens after isolated and combined injections of poly-L-lactic acid and hyaluronic acid

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Authors

ATA.V. TimofeevSMS.V. MurakovAGA.M. Glavnova

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Overview

Comparative analysis confirms efficacy and safety of poly-L-lactic acid and hyaluronic acid injections in two patients, suggesting potential for combined treatment approaches.

Key Points

  • Significant upregulation of TGF-β1 expression was observed in skin following both PLLA and HA treatments, indicating positive skin remodeling effects.
  • Biopsy specimens showed increased hydration levels of collagen after administration of HA and the combination treatment, highlighting enhanced dermal health.
  • The study utilized a single-blind approach with injections administered to the anterior abdominal wall quadrants for reliable histological evaluation.
  • Absence of adverse events supports the safety profile of PLLA and HA when used alone or in combination, warranting further investigation.

Cite This Study

Timofeev et al. (2025) studied this question.

synapsesocial.com/papers/68d462c131b076d99fa61e50https://doi.org/10.17116/plast.hirurgia202503150
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of Tissue Response to Coinjection Versus Individual Injection of Hyaluronic Acid Filler and Polycaprolactone Microsphere‐Based Filler in a Rabbit Model2026
  2. 2Clinical applications of a novel poly‐L‐lactic acid microsphere and hyaluronic acid suspension for facial depression filling and rejuvenation2024 · 25 citations
  3. 3Collagen stimulation synergy of a hybrid protocol: combining high-intensity focused ultrasound (HIFU) and poly-L-lactic acid (PLLA) in facial rejuvenation2026 · 1 citations
  4. 4Clinical evaluation of the effect of non-crosslinked hyaluronic acid injections on skin parameters with signs of aging. Case study2025
  5. 5Exploring the Role of Poly‐ <scp>L</scp> ‐Lactic Acid in Dermatology2026