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May 24, 2026Journal of Cosmetic DermatologyOpen Access

Evaluation of Tissue Response to Coinjection Versus Individual Injection of Hyaluronic Acid Filler and Polycaprolactone Microsphere‐Based Filler in a Rabbit Model

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Authors

WXWen XieYTYuan TangCPCuiling Pu

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Overview

Randomized trial evaluates safety and tissue responses to combined dermal fillers in rabbits, highlighting favorable profiles.

Key Points

  • This study aims to compare the tissue reactions and safety of hyaluronic acid and polycaprolactone fillers, both individually and in combination.
  • Five experimental groups established with various injection sequences of HA and PCL fillers.
  • Histological evaluations conducted at 1, 2, and 3 months post-injection.
  • Injection directly into the back of rabbits to assess tissue responses.
  • PCL filler alone caused significant inflammation by month 3; HA filler resulted in minimal inflammation.
  • Combined injections alleviated inflammatory responses and improved microsphere dispersion compared to PCL alone.
  • Collagen deposition was low in HA groups, while PCL alone showed mild Type III collagen generation.

Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/6a12959d48a0ea1665671bd5https://doi.org/10.1111/jocd.70941
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Morphological and immunohistochemical characteristics of skin specimens after isolated and combined injections of poly-L-lactic acid and hyaluronic acid2025
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  4. 4PLLA and PDLLA Fillers: Linking Crystallinity and Mechanical Stability to Aggregation, Redispersion, and Collagen Formation.2026
  5. 5Cross‐Linked Sodium Hyaluronate Filler Containing Poly‐L‐Lactic Acid‐b‐Poly (Ethylene Glycol) Microspheres for Periorbital Rejuvenation: A Multimodal Assessment of Physicochemical, Preclinical, and Clinical Performance2026 · 2 citations