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September 18, 2025British Journal of Haematology

Clinical features, mutational landscape and their prognostic impact in Chinese paediatric patients with T‐cell lymphoblastic lymphoma

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Authors

YLYang LiBinzhou UniversityLJLing JinCapital Medical UniversityWLWei LiuArmy Medical University

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Overview

Observational analysis shows mutation relationships with survival in children with T-cell lymphoblastic lymphoma, suggesting targeted strategies.

Key Points

  • Patients with NOTCH1 mutations exhibited improved event-free survival.
  • Invasion of pleural effusion significantly impacted overall survival rates.
  • Ninety-two genes were found with recurrent mutations, influencing prognosis.
  • CREBBP, PTEN, and LYST mutations are linked to poorer outcomes.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d462d231b076d99fa623cfhttps://doi.org/10.1111/bjh.70097
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