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December 8, 2025Blood

Clinical characteristics and treatment evaluation of T-cell lymphoblastic lymphoma in Chinese children and adolescents：a multicenter clinical study of China-net childhood lymphoma-lbl-2017

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Authors

LFLi FuShanxi Agricultural UniversityYDYunpeng DaiWestlake UniversityLSLirong SunQingdao University

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Overview

Multicenter clinical study shows the therapeutic efficacy and prognostic factors in pediatric T-LBL, indicating critical treatment strategies.

Key Points

  • To analyze the clinical features and treatment outcomes of T-cell lymphoblastic lymphoma in children and adolescents.
  • Multicenter clinical study including 548 T-LBL patients from 29 centers in China.
  • Patients classified into low, intermediate, and high-risk groups based on clinical staging and treatment response.
  • Stratified treatment administered according to the CNCL-LBL-2017 protocol, with follow-up until December 2024.
  • Event-free survival rates at 5 years were 77.1±1.9% and overall survival rates were 84.2±1.6%.
  • In 68 cases with CNS involvement, the recurrence rate was 3.3%.
  • High-risk patients showed improved outcomes with high-intensity chemotherapy.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d73bhttps://doi.org/10.1182/blood-2025-7155
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  1. 1Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma2026
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  3. 3Analysis of the clinical characteristics and prognostic factors of multicenter childhood Burkitt leukemia2025
  4. 4Clinical features, mutational landscape and their prognostic impact in Chinese paediatric patients with T‐cell lymphoblastic lymphoma2025 · 1 citations
  5. 5Treatment outcomes and prognostic factors of patients with lymphoblastic lymphoma in East Asia2024 · 1 citations