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September 18, 2025Frontiers in ImmunologyOpen Access

From metabolic reprogramming to epigenetic modification: association network and targeted treatment strategy between histone lactylation and tumor progression

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Authors

YLYi LiFLFeng LuQSQian Shen

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Overview

This review explores how metabolic reprogramming correlates with histone lactylation in tumors, suggesting new therapeutic strategies.

Key Points

  • Histone lactylation is associated with poor tumor prognosis, indicating its role in tumor progression and immune dynamics.
  • Metabolic changes driven by lactate impact chromatin dynamics and gene expression, linking metabolism and epigenetics.
  • Exploring histone lactylation offers insights into tumor microenvironmental interactions and potential therapeutic targets.
  • Understanding the network of lactate regulation may provide new approaches for targeted cancer therapies.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d462d231b076d99fa625a1https://doi.org/10.3389/fimmu.2025.1542664
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactate and lactylation: molecular insights into histone and non-histone lactylation in tumor progression, tumor immune microenvironment, and therapeutic strategies2025 · 23 citations
  2. 2Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription2024 · 75 citations
  3. 3Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors2025 · 22 citations
  4. 4Protein lactylation in cancer: principles, programmes and therapeutic opportunities2026 · 1 citations
  5. 5Lactate metabolism and protein lactylation in cancer2026 · 7 citations