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September 18, 2025Biology Medicine & Natural Product ChemistryOpen Access

Immunomodulatory Activity of Chinese Betel (Peperomia pellucida L.) Extract on the Spleen Histopathology in a Murine Model of Gastroenteritis

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Authors

LSLisa SavitriFPFendy PrasetyawanYSYuneka Saristiana

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Overview

This study investigates the immunomodulatory effects of Peperomia pellucida extract on spleen damage in mice with gastroenteritis, suggesting its potential as a natural antiseptic agent.

Key Points

  • The highest dose of Peperomia pellucida extract significantly reduced spleen damage in the model of gastroenteritis.
  • At 500 mg/kg BW, spleen degeneration decreased by 9.08%, necrosis by 6.05%, and PMN infiltration by 18.45%.
  • Histopathological evaluation measured tissue response after infection with Escherichia coli in male Swiss mice.
  • Results suggest Peperomia pellucida may offer protective effects, highlighting its potential use in natural medicine.

Cite This Study

Savitri et al. (2025) studied this question.

synapsesocial.com/papers/68d462db31b076d99fa629b4https://doi.org/10.14421/biomedich.2025.141.447-452
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