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September 18, 2025Basic & Clinical Pharmacology & Toxicology

Recurrent Exposure to Amoxicillin Impairs Male Reproductive Function by Enhancing Oxidative Stress and DNA Fragmentation in the Testis of Swiss Albino Mice

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Authors

NANabila AkhtaraMBManuj Kr. BharaliMCMrinmoy Chakraborty

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Overview

This study demonstrates reproductive toxicity from amoxicillin in male mice, indicating risks to fertility and health.

Key Points

  • Recurrent exposure to amoxicillin significantly impairs male reproductive function, reducing fertility potential.
  • Experiments showed that amoxicillin exposure increased oxidative stress and DNA fragmentation in testicular cells.
  • Assessment included ultrastructural, sperm parameters, and histomorphology, providing comprehensive results.
  • Implications point to the need for antibiotic safety evaluation related to male reproductive health.

Cite This Study

Akhtara et al. (2025) studied this question.

synapsesocial.com/papers/68d462db31b076d99fa62a0ehttps://doi.org/10.1111/bcpt.70115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Probiotic Bacillus Clausii Protects against Amoxicillin-evoked Reproductive Dysfunction through Oxidative Stress Modulation2026
  2. 2Molecular signatures of amoxicillin phytotoxicity revealed by integrated cytogenetic, biochemical, and molecular docking analyses2026
  3. 3Genotoxic and oxidative stress responses induced by amoxicillin in milkfish Chanos chanos (Forsskål, 1775)2026
  4. 4Systemic Effects of Oral Antibiotics in Mice: A Combined Physiological and Molecular Approach2026
  5. 5Endosulfan induces reproductive & genotoxic effect in male and female Swiss albino mice2024 · 2 citations