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September 18, 2025Open Access

Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset

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Authors

ACAna Caroline Costa-da-SilvaRSRubina SharmaMAMarit H. Aure

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Overview

Atlas study highlights the role of exhausted-like effector CD8 T cells and myeloid cells in oral mucosal cGVHD pathogenesis.

Key Points

  • At cGVHD onset, exhausted-like effector CD8 T cells significantly correlated with disease severity.
  • Distinct populations of CD8 T cells, including inflammatory and exhausted-like clusters, were prevalent during cGVHD onset.
  • Single-cell RNA sequencing revealed a transition between CD8 T cell clusters contributing to tissue damage.
  • Impairment of regulatory CD4 T cell function may lead to unchecked CD8 T cell activity in cGVHD.

Cite This Study

Costa-da-Silva et al. (2025) studied this question.

synapsesocial.com/papers/68d462db31b076d99fa62a73https://doi.org/10.1101/2025.09.11.675642
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Also Consider

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  1. 1M1 macrophage and Treg crosstalk mapping at single-cell resolution in mucosal chronic graft-versus-host disease 39402025
  2. 2Macrophage—Treg immunopathology in mucosal chronic graft-versus-host disease defined by single-cell and spatial profiling 23096542026
  3. 3Transcriptomic Analysis Identifies Tfrchi Acinar Population As Possible Driver of Terminal Exhaustion via CEACAM1-TIM-3 axis 23096562026
  4. 4Oral inflammation and microbiome dysbiosis exacerbate chronic graft-versus-host disease2024 · 17 citations
  5. 5Investigating donor CD8+ T cell differentiation post-experimental aHSCT in GVHD target tissues 36392025