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November 25, 2025The Journal of ImmunologyOpen Access

M1 macrophage and Treg crosstalk mapping at single-cell resolution in mucosal chronic graft-versus-host disease 3940

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Authors

RSRubina SharmaASAna C. Costa da SilvaNKNoemi Kedei

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Overview

Single-cell RNA sequencing reveals altered M1 macrophage and Treg interactions in mucosal graft-versus-host disease, suggesting altered immune balance.

Key Points

  • This research aims to explore the cellular interactions in chronic graft-versus-host disease (cGVHD), focusing on macrophage and Treg crosstalk.
  • Utilized single-cell RNA sequencing to analyze macrophage subsets in oral mucosa
  • Employed spatial transcriptomics to assess macrophage distribution
  • Conducted spatial proximity analysis to evaluate Treg and M1 macrophage relationships
  • Identified increased M1 macrophage and altered Treg interactions in oral mucosa of cGVHD patients
  • Found significant expression of inflammatory markers such as IL-17 and CD86 in M1 macrophages
  • Revealed decreased presence of TIGIT+ Tregs, indicating disrupted immune homeostasis in cGVHD

Cite This Study

Sharma et al. (2025) studied this question.

synapsesocial.com/papers/692502c987af00ed34ac251ehttps://doi.org/10.1093/jimmun/vkaf283.1682
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Also Consider

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  1. 1Macrophage—Treg immunopathology in mucosal chronic graft-versus-host disease defined by single-cell and spatial profiling 23096542026
  2. 2Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset2025
  3. 3CSF-1R+ macrophages orchestrate human skin chronic graft-versus-host disease2025
  4. 4TIM3-Galectin9 axis drives CSF-1R–independent senescent macrophage and TSCM crosstalk in chronic graft-versus-host disease2025
  5. 5Spatial communication modules identify prognostic cell-cell signaling hubs in chronic graft-versus-host disease2025