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December 8, 2025BloodOpen Access

CSF-1R+ macrophages orchestrate human skin chronic graft-versus-host disease

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Authors

JBJulie R. BoikoAEAnna ElzRARachael Adams

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Overview

Spatial transcriptomics uncovers CSF-1R+ macrophages' role in skin immune responses and therapy implications for chronic graft-versus-host disease.

Key Points

  • To analyze immune cell infiltration and responses in human skin affected by chronic graft-versus-host disease (cGVHD).
  • Utilized sub-cellular spatial transcriptomics with the 10x Xenium platform to study skin biopsies from cGVHD patients.
  • Examined immune cell populations such as macrophages and T cells before and after treatment with axatilimab.
  • Compared cGVHD histopathology with non-cGVHD biopsies for insights into disease pathology.
  • Identified distinct macrophage populations infiltrating high immune cell-infiltrated skin.
  • Noted aberrations in keratinocyte and fibroblast differentiation related to macrophage activity.
  • Responders to axatilimab showed marked reduction in CSF-1R+ macrophages and increased regulatory T cells in the skin.

Cite This Study

Boiko et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d960https://doi.org/10.1182/blood-2025-588
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