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December 8, 2025BloodOpen Access

Targeting hedgehog signaling/KL4-dependent M2 macrophage polarization for treatment of chronic graft-versus-host diseases and tissue fibrosis

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Authors

YYYiping Yang

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Overview

Findings reveal targeting hedgehog signaling and M2 macrophage polarization improves outcomes in cGVHD and fibrosis.

Key Points

  • To explore the role of hedgehog signaling and M2 macrophage polarization in chronic graft-versus-host disease (cGVHD) and tissue fibrosis.
  • Used murine models to investigate M2 macrophage polarization and its effects on cGVHD.
  • Analyzed immune microenvironments in tissues of mice and human patients with cGVHD.
  • Tested hedgehog and KLF4 inhibitors in a combination therapy approach for efficacy.
  • Higher levels of M2 macrophages and hedgehog signaling genes were found in cGVHD tissues compared to controls.
  • Inhibitors of hedgehog signaling and KLF4 improved survival and reduced fibrosis in cGVHD mice.
  • Combination therapy showed greater effectiveness than monotherapy in reducing tissue damage and collagen fibrosis.

Cite This Study

Yiping Yang (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d92chttps://doi.org/10.1182/blood-2025-583
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