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December 8, 2025Blood

TIM3-Galectin9 axis drives CSF-1R–independent senescent macrophage and TSCM crosstalk in chronic graft-versus-host disease

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Authors

FTFengjuan TianRWRui WangQSQingxiao Song

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Overview

Analysis reveals CSF-1R-independent senescent macrophage interactions with TSCM, suggesting novel therapeutic targets for cGVHD.

Key Points

  • To investigate the resistance mechanisms in chronic graft-versus-host disease (cGVHD) and identify potential therapeutic targets.
  • Analyzed human cGVHD skin and murine cGVHD target organs using single-cell RNA sequencing and flow cytometry.
  • Conducted functional assays and CellChat analysis to elucidate interactions between macrophages and TSCM.
  • Tested TIM3-Fc fusion protein therapeutically.
  • Identified hypoxic niches in cGVHD patients fostering interactions between macrophages and TSCM.
  • Observed expansion of specific macrophage and TSCM populations in target organs like the liver and lung.
  • TIM3-Fc administration significantly reduced inflammatory factors and disrupted macrophage-TSCM crosstalk.

Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236daafhttps://doi.org/10.1182/blood-2025-4085
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