Arrhythmia prevention protocol during papaverine administration for invasive coronary functional assessment

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Discussion

Prospective study shows lidocaine may reduce arrhythmias during papaverine-induced hyperemia in coronary patients, indicating enhanced safety.

Lidocaine pre-treatment led to only 1.5% of patients experiencing ventricular arrhythmias, enhancing safety.
Significant stenosis was found in 36% of patients, indicating the need for effective coronary assessment.
Intracoronary papaverine effectively induced hyperemia, but traditional use raised arrhythmia concerns.
289 patients exhibited microvascular dysfunction, underscoring the complexity of coronary physiology.

Vassilev et al. (2025) studied this question.

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Prospective study shows lidocaine may reduce arrhythmias during papaverine-induced hyperemia in coronary patients, indicating enhanced safety.