Key result
Intracoronary papaverine linked to ~60 ms QTc prolongation and occasional serious ventricular arrhythmias.
Why the study?
The incidence and risk of ventricular arrhythmias following intracoronary injection of papaverine were not well characterized.
Does intracoronary papaverine cause QT prolongation and ventricular arrhythmias?
Population
42 patients undergoing intracoronary papaverine injection with a 3F coronary Doppler catheter in the proximal LAD
Comparison
Before and after intracoronary papaverine injection
Design
Observational cohort study
Follow-up
Immediate post-injection
Authors
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Intracoronary papaverine was associated with QT prolongation and arrhythmias; leaves open causality and need for randomized safety trials.
Observational (n=42)
Does intracoronary papaverine cause QT prolongation and ventricular arrhythmias?
Absolute Event Rate: 0.49% vs 0.43%
p-value: p=<0.001
Intracoronary papaverine can cause significant QT prolongation and potentially serious ventricular arrhythmias, necessitating careful use.
Inoue et al. (2008) reported an observational. Intracoronary papaverine vs. Baseline was evaluated on Corrected QT interval (p=<0.001). Intracoronary injection of papaverine significantly prolonged the corrected QT interval from 0.43 to 0.49 seconds (p<0.001) and was associated with occasional serious ventricular arrhythmias.
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