Key result
Intracoronary papaverine administration significantly prolonged QT intervals across all patient groups (P<0.01), with rare but serious idiosyncratic ventricular dysrhythmias observed.
Why the study?
Does intracoronary papaverine cause QT interval prolongation and ventricular dysrhythmias in patients undergoing coronary angiography or angioplasty?
Population
34 patients undergoing coronary angiography or angioplasty, including 20 patients with angiographically…
Comparison
Intracoronary papaverine vs Baseline (prior to papaverine administration)
Design
Cohort
Authors
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Supports antiarrhythmic preparedness with intracoronary papaverine; extends prior observations in contemporary cohort but leaves open randomized safety confirmation.
Observational (n=34)
No
Does intracoronary papaverine cause QT interval prolongation and ventricular dysrhythmias in patients undergoing coronary angiography or angioplasty?
p-value: p=<0.01
Intracoronary papaverine commonly causes significant QT interval prolongation and can lead to idiosyncratic, severe ventricular dysrhythmias, necessitating the availability of antiarrhythmic preparations.
Kern et al. (1990) conducted an observational in Patients undergoing intracoronary papaverine administration (n=34). Intracoronary papaverine vs. Baseline was evaluated on QT interval prolongation (p=<0.01). Intracoronary papaverine administration significantly prolonged QT intervals across all patient groups (P<0.01), with rare but serious idiosyncratic ventricular dysrhythmias observed.
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