Key result
Intracoronary administration of papaverine induced excessive QT prolongation, torsade de pointes, and ventricular fibrillation in a patient with a history of drug-induced QT prolongation.
Population
A 64-year-old woman with a history of hypertension, paroxysmal atrial fibrillation, and bepridil-induced QT…
Design
Case_report
Authors
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Caution with intracoronary papaverine in patients with prior drug-induced QT prolongation; single case leaves open broader risk assessment in FFR.
Case Report (n=1)
No
A history of drug-induced QT prolongation may serve as a risk factor for papaverine-induced fatal ventricular arrhythmias during coronary fractional flow reserve studies.
Goto et al. (2014) conducted a case report in Coronary artery disease and history of drug-induced QT prolongation (n=1). Papaverine hydrochloride was evaluated on Development of QT prolongation, torsade de pointes, and ventricular fibrillation. Intracoronary administration of papaverine induced excessive QT prolongation, torsade de pointes, and ventricular fibrillation in a patient with a history of drug-induced QT prolongation.
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