Key result
Intracoronary administration of papaverine during fractional flow reserve measurement induced polymorphic ventricular tachycardia in 2.8% of patients and ventricular fibrillation in 1.7%, preceded by excessive QT and QTU prolongation.
Why the study?
Does intracoronary papaverine administration induce malignant ventricular arrhythmias in patients undergoing FFR measurement?
Population
182 consecutive patients with moderate coronary artery disease undergoing fractional flow reserve…
Comparison
Intracoronary papaverine administration vs Patients without ventricular tachycardia
Design
Cohort
Follow-up
Immediate (during procedure)
Authors
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Alerts to VA risk during papaverine FFR; leaves open safer agents and risk-stratification criteria.
Observational (n=182)
Yes
Does intracoronary papaverine administration induce malignant ventricular arrhythmias in patients undergoing FFR measurement?
Intracoronary papaverine for FFR measurement carries a rare but unpredictable risk of fatal ventricular tachyarrhythmias preceded by excessive QT prolongation.
Nakayama et al. (2015) conducted an observational in Moderate coronary artery disease (n=182). Intracoronary papaverine vs. Baseline (pre-administration) was evaluated on Incidence of polymorphic ventricular tachycardia (torsade de pointes). Intracoronary administration of papaverine during fractional flow reserve measurement induced polymorphic ventricular tachycardia in 2.8% of patients and ventricular fibrillation in 1.7%, preceded by excessive QT and QTU prolongation.
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