Why the study?
Does intracoronary papaverine affect myocardial performance in a dog model with reduced coronary flow reserve?
Population
9 anaesthetized open-chest dogs with a bypass from the aorta to the left circumflex coronary artery and…
Comparison
Intracoronary injection of papaverine into the… vs Baseline/control state prior to injection
Design
Preclinical
Follow-up
Transient (about 1 min following injection)
Authors
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Caution advised for intracoronary papaverine in reduced flow reserve; leaves open human translation.
Does intracoronary papaverine affect myocardial performance in a dog model with reduced coronary flow reserve?
Intracoronary papaverine transiently impairs regional and global ventricular function in a dog model with reduced coronary flow reserve, likely due to subendocardial ischemia from blood flow redistribution.
Schad et al. (1991) studied this question.
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