A complete Sigmodon hispidus genome and dynamic single-cell transcriptomics reveal evolutionarily conserved responses to RSV infection

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This research reveals conserved responses to RSV infection in sigmodon hispidus, highlighting its significance as a model organism.

Cotton rats show conservation of respiratory cell profiles with humans, supporting their use as an RSV model.
Phylogenetic analysis confirms distinct evolutionary branches of sigmodon hispidus from common laboratory rodents.
Single-cell transcriptomics highlight changes in alveolar cells and potential viral receptors during RSV infection.
The study identifies candidate host factors and antiviral proteins that could serve as clinical markers in humans.

Qin et al. (2025) studied this question.

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