Key result
Live EV-D68 immunization clears virus in cotton rats but worsens lung pathology via strong cytokine responses.
Why the study?
Does EV-D68 immunization or prophylactic serum administration prevent viral replication in a cotton rat model?
Population
Adult cotton rats (Sigmodon hispidus)
Comparison
Intranasal infection with EV-D68 strains… vs Mock-immunized, uninfected, or UV-inactivated…
Design
Preclinical
Follow-up
Up to 9 weeks
Authors
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Live EV-D68 immunization clears virus yet enhances lung pathology in cotton rats; leaves open safe vaccine strategies for clinical translation.
Does EV-D68 immunization or prophylactic serum administration prevent viral replication in a cotton rat model?
The cotton rat is a permissive animal model for EV-D68 infection, providing a platform to study pathogenesis, immune responses, and vaccines.
Patel et al. (2016) studied Enterovirus D-68 infection. EV-D68 (VANBT/1, MO/14/49, ATCC strains) infection and immunization vs. UV-inactivated virus or mock (PBS) was evaluated on Viral replication in nose and lung tissues, neutralizing antibody production, and protection against challenge. Intramuscular immunization of cotton rats with live EV-D68 VANBT/1 resulted in complete virus clearance upon challenge, but induced strong pulmonary Th1 and Th2 cytokine responses and enhanced lung pathology.
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