Population
One-month-old cotton rats (Sigmodon hispidus)
Design
Preclinical
Follow-up
28 days
Authors
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Supports cotton rat model for adenovirus studies; leaves open translation to clinical practice.
Cotton rats infected with adenovirus type 5 demonstrate pulmonary histopathology and viral replicative patterns similar to natural human disease, establishing them as a viable animal model.
Pacini et al. (1984) studied this question.
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