Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 19, 2025Open Access

Targeting human M2 macrophages with antibodies in optimized 3D tumor spheroids

View Full Paper
Ask AI
Bookmark
Share

Authors

CBChloe BazileFGFabien GavaFRFlavien Raynal

Discussion

Loading...

Member takes

Overview

In vitro model targets pro-tumoral macrophages in tumor microenvironment, suggesting new approaches for immuno-oncology.

Key Points

  • Specifically targeting pro-tumoral macrophages can reduce their immunosuppressive effects on cancer growth.
  • The study demonstrates effective antibody targeting in a 3D model with cancer cells and macrophages.
  • Developing in vitro models is critical for understanding tumor microenvironment interactions and treatment strategies.
  • Using optimized 3D tumor spheroids, this approach may lead to better therapeutic tools against tumor-associated macrophages.

Cite This Study

Bazile et al. (2025) studied this question.

synapsesocial.com/papers/68d464e031b076d99fa63d15https://doi.org/10.1101/2025.09.16.676563
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The pivotal role of macrophages in tumorigenesis and pioneering cancer immunotherapy across pre-clinical and clinical frontiers2026
  2. 2A New Perspective in Tumor Therapy: Targeting M2-Type Tumor-Associated Macrophages2026
  3. 3In vitro functional assays to assess the reciprocal interplay between tumor cells and macrophages2024 · 1 citations
  4. 4Progress in targeting tumor-associated macrophages in cancer immunotherapy2025 · 39 citations
  5. 5Tumor-associated macrophages in cancer: from mechanisms to application2025 · 25 citations