This method promotes C─H alkylation in azauracils and hydroxamic acids, indicating efficiency and broad applications.
A visible‐light‐induced alkylation of azauracils was developed via the site‐selective 1,5‐hydrogen atom transfer of hydroxamic acid derivatives. The cross‐dehydrogenative coupling reaction between C(sp 2 )─H bond in azauracils and the γ‐C(sp 3 )─H bond in hydroxamic acid derivatives was involved. Notable features of this protocol include its mild and metal‐free reaction conditions, significant atom/step efficiency, broad substrate scope, and its application in the late‐stage modification of pharmaceutical compounds.
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Qu et al. (2025) studied this question.
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