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This is a Quantitative Study study.

September 20, 2025Open Access

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis

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This analysis reveals uncoupled mechanisms of stemness loss and lineage acquisition in hematopoiesis, highlighting gene regulatory networks.

The study demonstrates how stemness loss precedes lineage acquisition during hematopoiesis, indicating distinct regulatory processes.
Dynamic enhancer-based gene regulatory networks were established, integrating transcription factor abundance, accessibility, and gene expression.
Using a trimodal framework, the research reconciles continuous and discrete models of hematopoietic cell populations.
The findings support the definition of cell types based on their regulatory logic, establishing a novel resource for further research.

Palii et al. (2025) studied this question.

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September 20, 2025Open Access

View Full Paper

Ask AI

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Authors

This analysis reveals uncoupled mechanisms of stemness loss and lineage acquisition in hematopoiesis, highlighting gene regulatory networks.

The study demonstrates how stemness loss precedes lineage acquisition during hematopoiesis, indicating distinct regulatory processes.
Dynamic enhancer-based gene regulatory networks were established, integrating transcription factor abundance, accessibility, and gene expression.
Using a trimodal framework, the research reconciles continuous and discrete models of hematopoietic cell populations.
The findings support the definition of cell types based on their regulatory logic, establishing a novel resource for further research.

Palii et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark