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September 20, 2025BMC GastroenterologyOpen Access

Global burden of cirrhosis and other chronic liver diseases caused by specific etiologies from 1990 to 2021

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Authors

YZYing ZhangSouth China Agricultural UniversityMLMing LuoGuangxi Normal UniversityYMYingzi MingCentral South University

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Overview

Analysis reveals escalating NAFLD-related cirrhosis in various regions, suggesting urgent public health interventions.

Key Points

  • NAFLD-related cirrhosis shows a significant increase in age-standardized incidence rate from 1990 to 2021.
  • Stable or declining trends observed for viral and alcohol-related cirrhosis, emphasizing a shift towards metabolic causes.
  • Estimated annual percentage change highlighted the growing challenge of NAFLD in both high and low-income countries.
  • Effective control of HBV and HCV-related mortality in high-SDI countries contrasts with rising NAFLD cases in lower-SDI regions.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d469d631b076d99fa66ffbhttps://doi.org/10.1186/s12876-025-04264-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contemporary global epidemiology of cirrhosis2026
  2. 2Changing global epidemiology of chronic hepatitis C virus-related outcomes from 2010 to 2019: cirrhosis is the growing burden of hepatitis C virus-related disease2024 · 6 citations
  3. 3Global landscape of liver disease burden in 1990–20212026
  4. 4An analysis of the global, regional, and national burden of liver cirrhosis in older adults from 1990 to 20212026
  5. 5Global burden of chronic liver disease due to NAFLD from 2012 to 2021: A trend, decomposition, and health inequality analysis2025 · 5 citations