This article demonstrates the conversion of alkynes to 1,2-dicarbonyls in organic synthesis, highlighting iodination and Kornblum oxidation methods.
The 1,2-dicarbonyls are excellent moieties in organic synthesis and they offer scope for the synthesis of numerous interesting heterocycles. Likewise, the alkynes are widespread in nature and drugs. Herein, the present article highlights the application of alkynes in organic synthesis as 1,2-dicarbonyl surrogates by I2/DMSO and NIS/DMSO mediated oxidations through a cascade of iodination and Kornblum oxidation. These approaches are mild, efficient, and tolerate many functional groups. The NIS/DMSO, and iodine-DMSO mediated oxidation of alkynes to 1,2-dicarbonyl compounds and trapping by several nucleophiles to construct important diversely functionalized heterocycles have been discussed in this article. The state of art, challenges, and future perspective have been highlighted in the present collection.
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Acharya et al. (2025) studied this question.
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